Two years have passed since the last season. Jin and Saki develop a sweet confectionery that contains medicine for Saki's mother who has a severe case of beriberi. Meanwhile, Ryoma asks Jin to care for Kaishuu Katsu's mentor, Shozan Sakuma. Shozan is in a critical state after being attacked by the Shinsengumi. Jin is reluctant because curing Shozan would mean changing the course of history. However, Shozan tells him that he too is involved in the “present”.
Episode 1
Episode 1
Apr 17, 2011
Jin examines Saki’s ill mother after learning that she may have beriberi disease due to malnutrition. Ryoma arrives from Kyoto seeking Jin’s help.
Episode 2
Episode 2
Apr 24, 2011
Jin considers the risks of interfering with history by treating an imperial princess with suspected beriberi. An old acquaintance appears before him.
Episode 3
Episode 3
May 1, 2011
Locked away in prison for a crime he didn’t commit, Jin endures harsh conditions and torture. Ryoma and Kyotaro fight to prove his innocence.
Episode 4
Episode 4
May 8, 2011
As the Jinyudo doctors continue trying to create penicillin in powder form, Taki asks Jin for help in treating a noblewoman from an important family.
Episode 5
Episode 5
May 15, 2011
Jin does all he can to help a renowned kabuki actor suffering from severe lead poisoning and limb paralysis to perform on stage one last time.
Episode 6
Episode 6
May 22, 2011
While visiting Nagasaki to teach other doctors about penicillin, Jin catches up with Ryoma but senses that something about him has changed.
Episode 7
Episode 7
May 29, 2011
After receiving a wedding invitation from Nokaze, Saki and Jin go to Yokohama for the occasion. But during the visit, Nokaze wants Jin to examine her.
Episode 8
Episode 8
Jun 5, 2011
As Ryoma fully devotes himself to achieving a return to imperial rule, Jin battles to protect the lives of both a struggling Nokaze and her child.
Episode 9
Episode 9
Jun 12, 2011
As Jin rushes to Kyoto with Saki and Saburi to prevent Ryoma’s assassination, Kyotaro heads for the same destination with a very different mission.
Episode 10
Episode 10
Jun 19, 2011
Jin, Saki and Saburi perform a major surgery to try and save Ryoma’s life. The Jinyudo doctors face charges of teaching how to create fake penicillin.
Episode 11
Episode 11
Jun 26, 2011
Sensing he has little time left, Jin resolves to pass on his entire medical knowledge to the Jinyudo doctors. Kyotaro makes a difficult decision.